ACIDOSIS O N INTRACELLULAR pH A N D LACTATE METABOLISM I N T H E ISOLATED PERFUSED RAT LIVER
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چکیده
1. The relationship between extracellular pH (pH,), intracellular pH (pH,) and lactate uptake was studied in the isolated perfused rat liver during simulated metabolic acidosis. 2. pHi fell to a considerably less extent than pH, when the latter was decreased from pH 7.4 to 6.7. 3. The liver took up lactate when pHi was greater than 7.0; at lower values of pH, lactate output occurred. 4. The relevance of these observations to the control of hepatic pHi and lactate metabolism is discussed.
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7 Assal JP, Aoki TT, Manzano FM, Kozak GP. Metabolic effects of sodium bicarbonate in the management of diabetic ketoacidosis. Diabetes 1974;23 :405-11. 8 Bureau MA, Begin R, Berthianne Y, Shapcott D, Khoury K, Gagnon N. Cerebral hypoxia from bicarbonate infusion in diabetic acidosis. J Pediatr 1980;96: 968-73. 9 Nattrass M, Hale PJ. Clinical aspects of diabetic ketoacidosis. In: Nattrass M, Sa...
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تاریخ انتشار 2012